Delayed Nogo receptor therapy improves recovery from spinal cord contusion
نویسندگان
چکیده
منابع مشابه
Recovery from chronic spinal cord contusion after Nogo receptor intervention.
OBJECTIVE Several interventions promote axonal growth and functional recovery when initiated shortly after central nervous system injury, including blockade of myelin-derived inhibitors with soluble Nogo receptor (NgR1, RTN4R) decoy protein. We examined the efficacy of this intervention in the much more prevalent and refractory condition of chronic spinal cord injury. METHODS We eliminated th...
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Traumatized axons possess an extremely limited ability to regenerate within the adult mammalian CNS. The myelin-derived axon outgrowth inhibitors Nogo, oligodendrocyte-myelin glycoprotein, and myelin-associated glycoprotein, all bind to an axonal Nogo-66 receptor (NgR) and at least partially account for this lack of CNS repair. Although the intrathecal application of an NgR competitive antagoni...
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ژورنال
عنوان ژورنال: Annals of Neurology
سال: 2006
ISSN: 0364-5134,1531-8249
DOI: 10.1002/ana.20953